Alain LE MOINEMD, PhD
We aim to investigate the regulation of innate and adaptive immunity (B and T cells) in the context of solid organ and stem cell transplantation, during immune mediated damages associated with ischemia reperfusion injury (mainly acute kidney injury –AKI-) and unsuited or desired weak immune responses towards defined antigens (such as minor transplantation antigens or anti-tumor immunity). Today, we are mainly focusing on the role of heme oxygenase (HO)-1 in these contexts. By combining mouse experimental models of graft versus host disease (GVHD), graft versus leukemia (GVL) effect, minor or major (single or multiple) MHC mismatched skin allograft models, acute or chronic kidney injury models and tumor models, we try to decipher dominant pathways of regulatory cross-talks between T cells, myeloid cells and other cells. Those experimental models are conducted in parallel with clinical studies of patient’s cohort’s for instance testing hypothesis of some gene polymorphisms that might be associated with different patient or transplant outcomes. Projects are conducted by MD Post-docs, MD PhD students, directly involved in academic medicine and PhD.