Institute for Medical Immunology

Master students wanted

IMI is seeking highly motivated students who wish to carry out their Master thesis in the field of immunology. The institute offers the latest laboratory equipment and research facilities. The possibility of undertaking a PhD at IMI after their Master will be given to students who have demonstrated a strong ability to academic research.

Research project Proposals

  • Transcriptional control of memory CD8 T cell differentiation

    Cytotoxic T lymphocytes play an important role for the protection of the host. Upon infection, these lymphocytes rapidly proliferate and kill infected cells. After this phase, a small fraction of these activated cells remains in the organism as «memory» cells, allowing the body to react more rapidly and efficiently to a subsequent challenges. Some naïve cells may also acquire a memory phenotype in absence of infection or antigenic challenge. In this project, we will further delineate the molecular mechanisms implicated in differentiation and maintenance of these memory cells using transcriptomic and epigenomic approaches.
    Contact: S. Goriely (stgoriel@ulb.ac.be)


  • Understanding skin immune homeostasis

    Epithelial barriers such as gut and skin are continuously exposed to environmental stimuli, including commensal and pathogenic microbes. It is essential for the host to control inflammatory processes in order to promote tissue homeostasis and prevent local and systemic pathologies. Using transgenic mouse models of spontaneous inflammation, this project will study the interactions between immune cells, keratinocytes and skin microbiota.
    Contact: S. Goriely (stgoriel@ulb.ac.be)


  • Repertoire development in T regulatory cells (Treg)

    How T cells recognise specifically antigens is of prime interest in immunology. Several lines of evidence indicate that the elongation of the TCR CDR3 region impacts the affinity of the TCR for antigen peptide/MHC complexes. The project will study how CDR3 length affects the functional development of regulatory and effector T cells in both animal and human models using high-throughput RNAseq and single cell PCR technologies.
    Contacts: A. Marchant (arnaud.marchant@ulb.ac.be) et M.Braun (mbraun@ulb.ac.be)