Institute for Medical Immunology

List of publications


Kollmann TR, A Marchant. Immunity and immunopathology in early human life. 2017. Seminars in Immunopathology. 39 :575-576.

Molès JP, Tuaillon E, Kankasa C, Bedin AS, Nagot N, Marchant A, McDermid JM, Van de Perre P. Breast milk cells trafficking induces microchimerism-mediated immune system maturation in the infant. Pediatr Allergy Immunol. 2017. doi: 10.1111/pai.12841.

Kollmann TR, A Marchant. Host defense mechanisms against bacteria. In Fetal and Neonatal Physiology, Fifth Edition. Ed. R Polin, S Abman, W Benitz, D Rowitch. Elsevier. 2017. Volume 1: 1163-1171.

Muraille E, Goriely S. The nonspecific face of adaptive immunity. 2017 Curr Opin Immunol. Aug 17;48:38-43. doi: 10.1016/j.coi.2017.08.002.

M. Coccia, C. Collignon, C. Hervé, A. Chalon, I. Welsby, S. Detienne, M. J. van Helden, S. Dutta, C. J. Genito, N. C. Waters, K. Van Deun, A. K. Smilde, R. A. van den Berg, D. Franco, P. Bourguignon, S. Morel, N. Garçon, B. N. Lambrecht, S. Goriely, R. van der Most, and A. M. Didierlaurent, “Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity, 2017 npj Vaccines, vol. 2 no1 p25

Dantoft W, P Martínez-Vicente, J Jafali, L Pérez-Martínez, K Martin, K Kotzamanis, M Craigon, NT Young, P Walsh, A Marchant, A Angulo, T Forster, P Ghazal. Genomic programming of human neonatal myeloid-dendritic cells in congenital systemic and in vitro cytomegalovirus infection reveal plastic and robust immune pathway biology responses. 2017. Frontiers in Immunology. 8:1146.

Tosolini M, Pont F, Poupot M, Vergez F, Nicolau-Travers ML, Vermijlen D, Sarry JE, Dieli F, Fournié JJ. Assessment of tumor-infiltrating TCRVγ9Vδ2 γδ lymphocyte abundance by deconvolution of human cancers microarrays. Oncoimmunology 2017 Feb 6;6(3):e1284723

Roger T, Schlapbach LJ, Schneider A, Weier M, Wellmann S, Marquis P, Vermijlen D, Sweep FC, Leng L, Bucala R, Calandra T, Giannoni E. Plasma Levels of Macrophage Migration Inhibitory Factor and d-Dopachrome Tautomerase Show a Highly Specific Profile in Early Life. Front Immunol. 2017 Jan 25;8:26.

Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G, Bonte S, Taghon T, Leclercq G, Kerre T, Debets R, Vermijlen D, Abken H and Vandekerckhove B. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities. Oncoimmunology 2017 Jan 19;6(3):e1283460.

Verstichel G, Vermijlen D, Martens L, Goetgeluk G, Brouwer M, Thiault N, Van Caeneghem Y, De Munter S, Weening K, Bonte S, Leclercq G, Taghon T, Kerre T, Saeys Y, Cheroutre H, Vandekerckhove B. The checkpoint for agonist selection precedes conventional selection in human thymus. Science Immunology 2017 2: eaah4232.

Van hede D, Polese B, Humblet C, Wilharm A, Renoux V, Dortu E, Laurence de Leval, Delvenne P, Desmet CJ, Bureau F, Vermijlen D, Jacobs N*, Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation. PNAS 2017 early edition October 10.

Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA, Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ; EGPA Mepolizumab Study Team. Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis. N Engl J Med. 2017 May 18;376(20):1921-1932.

Garaud S, Roufosse F, De Silva P, Gu-Trantien C, Lodewyckx JN, Duvillier H, Dedeurwaerder S, Bizet M, Defrance M, Fuks F, Bex F, Willard-Gallo K. FOXP1 is a regulator of quiescence in healthy human CD4+ T cells and is constitutively repressed in T cells from patients with lymphoproliferative disorders. Eur J Immunol. 2017 Jan;47(1):168-179.

Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury. Rossi M, Thierry A, Delbauve S, Preyat N, Soares MP, Roumeguère T, Leo O, Flamand V, Le Moine A, Hougardy JM. Sci Rep. 2017 Mar 15;7(1):197. doi: 10.1038/s41598-017-00220-w.

Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis. Zheng F, Sparkes A, De Baetselier P, Schoonooghe S, Stijlemans B, Muyldermans S, Flamand V, Van Ginderachter JA, Devoogdt N, Raes G, Beschin A. Mol Imaging Biol. 2017 Feb;19(1):49-58. doi: 10.1007/s11307-016-0976-3.

Kollmann TR, B Kampmann, S Mazmanian, A Marchant, O Levy. Protecting the newborn and young infant from infectious diseases : lessons from immune ontogeny. 2017. Immunity. 46: 350-363.

Marchant A, M Sadarangani, M Garand, N Dauby, V Verhasselt, L Pereira, G Bjornson, CE Jones, SA Halperin, KM Edwards, P Heath, PJ Openshaw, DW Scheifele, TR Kollmann. Maternal Immunisation: Collaborating with Mother Nature. 2017. The Lancet Infectious Diseases.

Molès JP, E Tuaillon, C Kankasa, AS Bedin, N Nagot, A Marchant, JM McDermid, P Van de Perre. Breastfeeding-related maternal microchimerism. 2017. Nature Reviews Immunology. doi:10.1038/nri.2017.115 .

Jennewein MF, B Abu-Raya, Y Jiang, G Alter, A Marchant. Transfer of maternal immunity and programming of the newborn immune system. 2017. Seminars in Immunopathology. doi: 10.1007/s00281-017-0653-x.

Delforge ML, E Costa, F Brancart, D Goldman, I Montesinos, S Zaytouni, A Marchant, C Donner. Presence of cytomegalovirus in urine and blood of pregnant women might be associated with fetal infection. 2017. Journal of Clinical Virology 90:14-17.

Burny W, A Callegaro, V Bechtold, F Clement, S Delhaye, L Fissette, M Janssens, G Leroux-Roels, A Marchant, R Van Den Berg, N Garçon, R Van der Most, A Didierlaurent. Different adjuvants induce common innate pathways that are associated with enhanced adaptive responses against a model antigen in humans. 2017. Frontiers in Immunology. 8:943.

Andrianne, M., Assabban, A., La, C., Mogilenko, D. D., Salle, D. S. D., Fleury, S., Doumont, G., Van Simaeys, G., Nedospasov, S. A. S., Blackshear, P. J., Dombrowicz, D. D., Goriely, S., & Van Maele, L. (2017, June). Tristetraprolin expression by keratinocytes controls local and systemic inflammation. JCI insight, 2(11). doi:10.1172/jci.insight.92979

Gu-Trantien, C., Migliori, E., Buisseret, L., de Wind, A., Brohée, S., Garaud, S., Noel, G., Dang Chi, V. L., Lodewyckx, J. N. J., Naveaux, C. C., Duvillier, H., Goriely, S., Larsimont, D., & Willard-Gallo, K. K. (2017). CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer. JCI insight, 2(11). doi:10.1172/jci.insight.91487


De Wilde V, Roufosse F, Hermine O. Clonal eosinophil and mast cell diseases: different in the same way? Expert Rev Hematol. 2016 Dec;9(12):1107-1109.

Bromberg L, Roufosse F, Pradier O, Delporte C, Van Antwerpen P, De Maertelaer V, Cogan E. Methylprednisolone-induced lymphocytosis in patients with immune mediated inflammatory disorders. Am J Med 2016 Jul;129(7):746-752.

Roufosse F, Heimann P, Lambert F, Sidon P, Bron D, Cottin V, Cordier J-F. Severe prolonged cough as presenting manifestation of FIP1L1-PDGFRA+ chronic eosinophilic leukaemia: a widely ignored association. Respiration 2016;91(5):374-9.

Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB.Chiadak JD, Arsenijevic T, Verstrepen K, Gregoire F, Bolaky N, Delforge V, Flamand V, Perret J, Delporte C.Mediators Inflamm. 2016;2016:1431789. Epub 2016 Nov 2.

Abu Raya B, TR Kollmann, A Marchant, DM MacGillivray. The immune system of HIV-exposed uninfected infants. 2016. Frontiers in Immunology 7:383.

Detienne, S., Welsby, I., Collignon, C., Wouters, S., Coccia, M. E. M., Delhaye, S. S., Van Maele, L., Thomas, S., Swertvaegher, M., Detavernier, A., Elouahabi, A., Goriely, S., & Didierlaurent, A. M. (2016, December). Central Role of CD169(+) Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01. Scientific reports, 6, 39475. doi:10.1038/srep39475

Welsby, I., & Goriely, S. (2016). Regulation of Interleukin-23 Expression in Health and Disease. Advances in experimental medicine and biology, 941, 167-189. doi:10.1007/978-94-024-0921-5_8

Welsby, I., Detienne, S., N'Kuli, F., Thomas, S., Wouters, S., Bechtold, V. V., De Wit, D., Gineste, R. R., Reinheckel, T. T., Elouahabi, A., Courtoy, P., Didierlaurent, A. M., & Goriely, S. (2016). Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21. Frontiers in immunology, 7, 663. doi:10.3389/fimmu.2016.00663

Boye L, Welsby I, Lund LD, Goriely S, Frøkiaer H. Plasma membrane Toll-like receptor activation increases bacterial uptake but abrogates endosomal Lactobacillus acidophilus induction of interferon-β. Immunology. 2016 Jul 21. doi: 10.1111/imm.12650.

Roufosse F, Heimann P, Lambert F, Sidon P, Bron D, Cottin V, Cordier JF. Severe Prolonged Cough as Presenting Manifestation of FIP1L1-PDGFRA+ Chronic Eosinophilic Leukaemia: A Widely Ignored Association. Respiration. 2016;91(5):374-9. doi: 10.1159/000446076. Epub 2016 May 12.

Bromberg L, Roufosse F, Pradier O, Delporte C, Van Antwerpen P, De Maertelaer V, Cogan E. Methylprednisolone-Induced Lymphocytosis in Patients with Immune-Mediated Inflammatory Disorders. Am J Med. 2016 Jul;129(7):746-752.e3. doi: 10.1016/j.amjmed.2016.02.013. Epub 2016 Mar 9.

Abu Raya B, K Smolen, F Willems, TR Kollmann, A Marchant. Transfer of Maternal Anti-Microbial Immunity to HIV-Exposed Uninfected Newborns. 2016. Frontiers in Immunology. 7:338. doi: 10.3389/fimmu.2016.00338.

Ruck C, B Reikie , A Marchant, TR Kollman, F Kakkar. Immune development and susceptibility to infectious diseases among HIV exposed uninfected infants. 2016. Frontiers in Immunology. 7:310. doi: 10.3389/fimmu.2016.00310.

Lauvau G, Goriely S. Memory CD8 T cells: Orchestrators and key players of innate immunity? PLoS Pathog. 2016 Sep 1;12(9):e1005722. doi: 10.1371/journal.ppat.1005722. eCollection 2016 Sep.

Bettonville M, D'Aria S, Braun MY. Metabolic programming in chronically stimulated T cells: lessons from cancer and viral infections. Eur.J.Immunol. 2016 46:1574-1582.

Martinet V, Goriely S. Virtual memory of cytotoxic T lymphocytes. Médecine Sciences. 2016. 32:236-238.

Iversen MM, Reinert LL, Thomsen MKM, Bagdonaite II, Nandakumar, R. R., Cheshenko, N. N., Prabakaran, T. T., Vakhrushev, S. S., Krzyzowska, M. M., Kratholm, S. S., Ruiz-Perez, F. F., Petersen, S. V. S., Goriely, S., Bibby, B. M. B., Eriksson, K., Ruland, J. J., Thomsen, A. R., Herold, B. B., Wandall, H. H., Frische, S. S., Holm, C. K. C., Paludan, S. R. (2015). An innate antiviral pathway acting before interferons at epithelial surfaces. Nature Immunology. 2016. 17:150-158.

Changing oral vaccine to inactivated polio vaccine might increase mortality. Fish EN, KL Flanagan, D Furman, SL Klein, TR Kollman, DL Jeppesen, O Levy, A Marchant, S Namachivaayam, MG Netea, M Plebanski, SL Rowland-Jones, F Shann, HC Whittle. 2016 The Lancet. 387:1054-1055.

Kollmann TR, A Marchant. Towards predicting protective vaccine responses in the very young. 2016. Trends in Immunology. 2016 doi: 10.1016/

Bayard C, H Lepetitcorps, A Roux, M Larsen, S Fastenackels, V Salle, V Vieillard, A Marchant, M Stern, J Boddaert, F Bajolle, V Appay, D Sauce. CMV-mediated memory-like NK cell inflation in human. 2016. European Journal of Immunology. 46 :1168-1179.

Leroux-Roels G, A Marchant, J Levy, P Van Damme, TF Schwarz, Y Horsmans, W Jilg, PG Kremsner, E Haelterman, F Clément, JJ Gabor, M Esen, A Hens, I Carletti, L Fissette, F Tavares Da Silva, W Burny, M Janssens, P Moris, AM Didierlaurent, R Van Der Most, N Garçon, P Van Belle, M Van Mechelen. Impact of adjuvants on CD4+ T cell and B cell responses to a protein antigen vaccine: results from a phase II, randomized, multicentre trial. Clinical Immunology. 2016. 169:16-27.


Freyne B, A Marchant, N Curtis. BCG-associated heterologous immunity, a historical perspective: experimental models and immunological mechanisms. 2015 Transactions of the Royal Society of Tropical Medicine and Hygiene. 109:46-51.

Dauby N, D Sartori, C Kummert, S Lecomte, E Haelterman, ML Delforge, C Donner, M Mach, A Marchant. Limited effector memory B cell response to envelope glycoprotein B during primary HCMV infection. 2015. Journal of Infectious Diseases. 213 :1642-1650.

Zhang J, Braun MY. Protoporphyrin treatment modulates susceptibility to experimental autoimmune encephalomyelitis in miR-155-deficient mice. PlosOne. 2015. 10:e014537.

Weatherly K, Bettonville M, Torres D, Kohler K, Goriely S, Braun MY. Functional profile of S100A4-deficient T cells. Immun Inflamm Dis. 2015. 3 (4):431–44

Adler C, Haelterman E, Barlow P, Marchant A, Levy J, Goetghebuer T. Severe Infec-tions in HIV-Exposed Uninfected Infants Born in a European Country. PLoS One. 2015 10(8):e0135375.

Roufosse F. Management of Hypereosinophilic Syndromes. Immunol Allergy Clin North Am. 2015 35(3):561-75.

Huygens A, Lecomte S, Tackoen M, Olislagers V, Delmarcelle Y, Burny W, Van Rysselberge M, Liesnard C, Larsen M, Appay V, Donner C, Marchant A. Functional Exhaustion Limits CD4+ and CD8+ T-Cell Responses to Congenital Cytomegalovirus Infection. J Infect Dis. 2015 212(3):484-94.

Roufosse F, de Leval L, van Krieken H, van Deuren M. Lymphocytic variant hypereo-sinophilic syndrome progressing to angioimmunoblastic T-cell lymphoma. Leuk Lym-phoma. 2015 56(6):1891-4.

Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S. Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun. 2015 6:7089.

Broeders N, Racapé J, Hamade A, Massart A, Hoang AD, Mikhalski D, Le Moine A, Vereerstraeten P. A new HLA allocation procedure of kidneys from deceased donors in the current era of immunosuppression. Transplant Proc. 2015 47(2):267-74.

Zhang J, Vandevenne P, Hamdi H, Van Puyvelde M, Zucchi A, Bettonville M, Weather-ly K, Braun MY. Micro-RNA-155-mediated control of heme oxygenase 1 (HO-1) is re-quired for restoring adaptively tolerant CD4+ T-cell function in rodents. Eur J Immunol. 2015 45(3):829-42.

Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, Marchant A, Vermij-len D. Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire. Proc Natl Acad Sci U S A. 2015 112(6):E556-65.

Sauvage D, Roufosse F, Sanoussi I, Massin M, Rooze S, De Ville A, Azzi N, Huy-brechts S, Dedeken L, Devalck C, Ferster A. Treatment-refractory hypereosinophilic syndrome responding to fludarabine in a 12-year-old boy. Leuk Lymphoma. 2015 25:1-3.

Marchant A, Kollmann TR. Understanding the ontogeny of the immune system to pro-mote immune-mediated health for life. Front Immunol. 2015 23;6:77.

Goubella A, Broeders N, Racapé J, Hamade A, Massart A, Hougardy JM, Hoang AD, Mikhalski D, Baudoux T, Gankam F, Madhoun P, Janssen F, Le Moine A, Nortier J, Vereerstraeten P. Patient and graft outcome in current era of immunosuppression: a single centre pilot study. Acta Clin Belg. 2015 70(1):23-9.

Compté N, Bailly B, De Breucker S, Goriely S, Pepersack T. Study of the association of total and differential white blood cell counts with geriatric conditions, cardio-vascular diseases, seric IL-6 levels and telomere length. Exp Gerontol. 2015 61:105-12.

Zedda L, Forleo-Neto E, Vertruyen A, Raes M, Marchant A, Jansen W, Clouting H, Aro-ra A, Beatty ME, Galli G, Del Giudice G, Castellino F. Dissecting the immune response to MF59-adjuvanted and nonadjuvanted seasonal influenza vaccines in children less than three years of age. Pediatr Infect Dis J. 2015 34(1):73-8.

Freyne B, Marchant A, Curtis N. BCG-associated heterologous immunity, ahistorical perspective: intervention studies in animal models of infectious diseases. Trans R Soc Trop Med Hyg. 2015 109(1):52-61.


Ysebrant de Lendonck L, Martinet V, Goriely S. Interferon regulatory factor 3 in adap-tive immune responses. Cell Mol Life Sci. 2014 71(20):3873-83.

Huygens A, Dauby N, Vermijlen D, Marchant A. Immunity to cytomegalovirus in early life. Front Immunol. 2014 5:552.

Roufosse F. Peripheral T-cell lymphoma developing after diagnosis of lymphocytic var-iant hypereosinophilic syndrome: misdiagnosed lymphoma or natural disease progres-sion? Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 118(4):506-10.

Dauby N, Kummert C, Lecomte S, Liesnard C, Delforge ML, Donner C, Marchant A. Primary human cytomegalovirus infection induces the expansion of virus-specific acti-vated and atypical memory B cells. J Infect Dis. 2014 210(8):1275-85.

Antoine P, Varner V, Carville A, Connole M, Marchant A, Kaur A. Postnatal acquisition of primary rhesus cytomegalovirus infection is associated with prolonged virus shed-ding and impaired CD4+ T lymphocyte function. J Infect Dis. 2014 210(7):1090-9.

De Kleer I, Willems F, Lambrecht B, Goriely S. Ontogeny of myeloid cells. Front Immu-nol. 2014 5:423.

Smolen KK, Cai B, Gelinas L, Fortuno ES 3rd, Larsen M, Speert DP, Chamekh M, Cooper PJ, Esser M, Marchant A, Kollmann TR. Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four conti-nents. J Immunol. 2014 193(6):3003-12.

Zhang J, Braun MY. PD-1 deletion restores susceptibility to experimental autoimmune encephalomyelitis in miR-155-deficient mice. Int Immunol. 2014 26(7):407-15.

Twite N, Andrei G, Kummert C, Donner C, Perez-Morga D, De Vos R, Snoeck R, Marchant A. Sequestration of human cytomegalovirus by human renal and mammary epithelial cells. Virology. 2014 460-461:55-65.

Marillier RG, Uyttenhove C, Goriely S, Marbaix E, Van Snick J. IL-27p28 is essential for parent-to-F1 acute graft-versus-host disease. Eur J Immunol. 2014 44(7):2064-73.

Vermijlen D, Braun MY, Marchant A. Do PI3-kinase mutations drive T cells insane? Cell Mol Immunol. 2014 11(4):320-2.

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cičin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fulöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J. New advances in CMV and immunosenescence. Exp Gerontol. 2014 55:54-62.

Vokaer B, Le Moine A. Autophagy for tolerance induction in transplantation. Am J Transplant. 2014 14(3):503-4.

Smolen KK, Ruck CE, Fortuno ES 3rd, Ho K, Dimitriu P, Mohn WW, Speert DP, Cooper PJ, Esser M, Goetghebuer T, Marchant A, Kollmann TR. Pattern recognition receptor-mediated cytokine response in infants across 4 continents. J Allergy Clin Immunol. 2014 133(3):818-26.e4.

Benahmed A, Kianda M, Ghisdal L, Broeders N, Massart A, Lemy A, Mikhalski D, Ho-ang AD, Donckier V, Sadis C, Le Moine A, Madhoun P, Racapé J, Wissing M, Abramowicz D. Ticlopidine and clopidogrel, sometimes combined with aspirin, only minimally increase the surgical risk in renal transplantation: a case-control study. Nephrol Dial Transplant. 2014 29(2):463-6.

Lemaire A, Trépo E, Ouziel R, Gustot T, Moreno C, Degré D, Minsart C, Quertinmont E, Vercruysse V, De Wilde V, le Moine O, Devière J, Abramowicz M, le Moine A, Lemmers A. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is not associ-ated with alcoholic liver disease severity. Hepatology. 2014 59(1):352-3.


Sadis C, Detienne S, Vokaer B, Charbonnier LM, Lemaître P, Spilleboudt C, Delbauve S, Kubjak C, Flamand V, Field KA, Goldman M, Benghiat FS, Le Moine A. The cholin-ergic anti-inflammatory pathway delays TLR-induced skin allograft rejection in mice: cholinergic pathway modulates alloreactivity. PLoS One. 2013 8(11):e79984.

Compté N, Boudjeltia KZ, Vanhaeverbeek M, De Breucker S, Pepersack T, Tassignon J, Trelcat A, Goriely S. Increased basal and alum-induced interleukin-6 levels in geriat-ric patients are associated with cardiovascular morbidity. PLoS One. 2013 8(11):e81911.

Vokaer B, Charbonnier LM, Lemaître PH, Spilleboudt C, Le Moine A. IL-17A and IL-2-expanded regulatory T cells cooperate to inhibit Th1-mediated rejection of MHC II dis-parate skin grafts. PLoS One. 2013 8(10):e76040.

Hougardy JM, Sadis C, Le Moine A. Ultrasonic stimulation of the cholinergic anti-inflammatory pathway for renal protection. J Am Soc Nephrol. 2013 24(9):1340-2.

Donckier V, Craciun L, Miqueu P, Troisi RI, Lucidi V, Rogiers X, Boon N, Degré D, Buggenhout A, Moreno C, Gustot T, Sainz-Barriga M, Bourgeois N, Colle I, Van Vlier-berghe H, Amrani M, Remmelink M, Lemmers A, Roelen DL, Claas FH, Reinke P, Sa-witzki B, Volk HD, Le Moine A, de Hemptinne B, Goldman M. Expansion of memory-type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and rapamycin. Transplantation. 2013 96(3):306-15.

Debock I, Jaworski K, Chadlaoui H, Delbauve S, Passon N, Twyffels L, Leo O, Flamand V. Neonatal follicular Th cell responses are impaired and modulated by IL-4. J Immunol. 2013 191(3):1231-9.

Molle C, Zhang T, Ysebrant de Lendonck L, Gueydan C, Andrianne M, Sherer F, Van Simaeys G, Blackshear PJ, Leo O, Goriely S. Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease. J Exp Med. 2013 210(9):1675-84.

Ysebrant de Lendonck L, Tonon S, Nguyen M, Vandevenne P, Welsby I, Martinet V, Molle C, Charbonnier LM, Leo O, Goriely S. Interferon regulatory factor 3 controls inter-leukin-17 expression in CD8 T lymphocytes. Proc Natl Acad Sci U S A. 2013 110(34):E3189-97.

Lemaître PH, Vokaer B, Charbonnier LM, Iwakura Y, Estenne M, Goldman M, Leo O, Remmelink M, Le Moine A. IL-17A mediates early post-transplant lesions after hetero-topic trachea allotransplantation in Mice. PLoS One. 2013 8(7):e70236.

Ysebrant de Lendonck L, Eddahri F, Delmarcelle Y, Nguyen M, Leo O, Goriely S, Marchant A. STAT3 signaling induces the differentiation of human ICOS(+) CD4 T cells helping B lymphocytes. PLoS One. 2013 8(7):e71029.

Compté N, Zouaoui Boudjeltia K, Vanhaeverbeek M, De Breucker S, Tassignon J, Trelcat A, Pepersack T, Goriely S. Frailty in old age is associated with decreased inter-leukin-12/23 production in response to toll-like receptor ligation. PLoS One. 2013 8(6):e65325.

Scheper W, van Dorp S, Kersting S, Pietersma F, Lindemans C, Hol S, Heijhuurs S, Sebestyen Z, Gründer C, Marcu-Malina V, Marchant A, Donner C, Plachter B, Vermij-len D, van Baarle D, Kuball J. γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia. Leukemia. 2013 27(6):1328-38.

Harfi I, Schandené L, Dremier S, Roufosse F. Eosinophils affect functions of in vitro-activated human CD3-CD4+ T cells. J Transl Med. 2013 11:112.

Levy O, Goriely S, Kollmann TR. Immune response to vaccine adjuvants during the first year of life. Vaccine. 2013 31(21):2500-5.

Roufosse F. L4. Eosinophils: how they contribute to endothelial damage and dysfunc-tion. Presse Med. 2013 42(4 Pt 2):503-7.

Lemaître PH, Vokaer B, Charbonnier LM, Iwakura Y, Field KA, Estenne M, Goldman M, Leo O, Remmelink M, Le Moine A. Cyclosporine A drives a Th17- and Th2-mediated posttransplant obliterative airway disease. Am J Transplant. 2013 13(3):611-20.

Roufosse FE, Kahn JE, Gleich GJ, Schwartz LB, Singh AD, Rosenwasser LJ, Denburg JA, Ring J, Rothenberg ME, Sheikh J, Haig AE, Mallett SA, Templeton DN, Ortega HG, Klion AD. Long-term safety of mepolizumab for the treatment of hypereosinophilic syn-dromes. J Allergy Clin Immunol. 2013 131(2):461-7.e1-5.


Valent P, Klion AD, Rosenwasser LJ, Arock M, Bochner BS, Butterfield JH, Gotlib J, Haferlach T, Hellmann A, Horny HP, Leiferman KM, Metzgeroth G, Matsumoto K, Reiter A, Roufosse F, Rothenberg ME, Simon HU, Sotlar K, Vandenberghe P, Weller PF, Gleich GJ. ICON: Eosinophil Disorders. World Allergy Organ J. 2012 5(12):174-81.

Vitry MA, De Trez C, Goriely S, Dumoutier L, Akira S, Ryffel B, Carlier Y, Letesson JJ, Muraille E. Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensa-ble function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice. Infect Immun. 2012 80(12):4271-80.

Vokaer B, Charbonnier LM, Lemaître PH, Le Moine A. Impact of interleukin-2-expanded regulatory T cells in various allogeneic combinations on mouse skin graft survival. Transplant Proc. 2012 44(9):2840-4.

Kollmann TR, Levy O, Montgomery RR, Goriely S. Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. Immunity. 2012 37(5):771-83.

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V, Vanhaesebroeck B. The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol. 2012 13(11):1045-54.

Charbonnier LM, Vokaer B, Lemaître PH, Field KA, Leo O, Le Moine A. CTLA4-Ig re-stores rejection of MHC class-II mismatched allografts by disabling IL-2-expanded regu-latory T cells. Am J Transplant. 2012 12(9):2313-21.

Weiss G, Maaetoft-Udsen K, Stifter SA, Hertzog P, Goriely S, Thomsen AR, Paludan SR, Frøkiær H. MyD88 drives the IFN-β response to Lactobacillus acidophilus in den-dritic cells through a mechanism involving IRF1, IRF3, and IRF7. J Immunol. 2012 189(6):2860-8.

Valent P, Klion AD, Horny HP, Roufosse F, Gotlib J, Weller PF, Hellmann A, Metzger-oth G, Leiferman KM, Arock M, Butterfield JH, Sperr WR, Sotlar K, Vandenberghe P, Haferlach T, Simon HU, Reiter A, Gleich GJ. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol. 2012 130(3):607-612.e9.

Wechsler ME, Fulkerson PC, Bochner BS, Gauvreau GM, Gleich GJ, Henkel T, Kol-beck R, Mathur SK, Ortega H, Patel J, Prussin C, Renzi P, Rothenberg ME, Roufosse F, Simon D, Simon HU, Wardlaw A, Weller PF, Klion AD. Novel targeted therapies for eosinophilic disorders. J Allergy Clin Immunol. 2012 130(3):563-71.

Antoine P, Olislagers V, Huygens A, Lecomte S, Liesnard C, Donner C, Marchant A. Functional exhaustion of CD4+ T lymphocytes during primary cytomegalovirus infec-tion. J Immunol. 2012 189(5):2665-72.

Charbonnier LM, Le Moine A. Rapamycin as immunosuppressant in murine transplan-tation model. Methods Mol Biol. 2012 821:435-45.

Roux A, Mourin G, Larsen M, Fastenackels S, Urrutia A, Gorochov G, Autran B, Donner C, Sidi D, Sibony-Prat J, Marchant A, Stern M, Sauce D, Appay V. Differential impact of age and cytomegalovirus infection on the γδ T cell compartment. J Immunol. 2013 191(3):1300-6.

Christensen JE, Fenger C, Issazadeh-Navikas S, Krug A, Liljestrøm P, Goriely S, Pa-ludan SR, Finsen B, Christensen JP, Thomsen AR. Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic cho-riomeningitis virus-infected central nervous system versus the periphery. J Virol. 2012 86(13):7384-92.

Braconnier P, Del Marmol V, Broeders N, Kianda M, Massart A, Lemy A, Ghisdal L, Le Moine A, Madhoun P, Racapé J, Abramowicz D, Wissing KM. Combined introduction of anti-IL2 receptor antibodies, mycophenolic acid and tacrolimus: effect on malignan-cies after renal transplantation in a single-centre retrospective cohort study. Nephrol Dial Transplant. 2012 27(6):2547-53.

Cogan E, Roufosse F. Clinical management of the hypereosinophilic syndromes. Ex-pert Rev Hematol. 2012 5(3):275-89; quiz 290.

Valent P, Gleich GJ, Reiter A, Roufosse F, Weller PF, Hellmann A, Metzgeroth G, Lei-ferman KM, Arock M, Sotlar K, Butterfield JH, Cerny-Reiterer S, Mayerhofer M, Van-denberghe P, Haferlach T, Bochner BS, Gotlib J, Horny HP, Simon HU, Klion AD. Pathogenesis and classification of eosinophil disorders: a review of recent develop-ments in the field. Expert Rev Hematol. 2012 5(2):157-76.

Dauby N, Goetghebuer T, Kollmann TR, Levy J, Marchant A. Uninfected but not unaf-fected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections. Lancet Infect Dis. 2012 12(4):330-40.

Roufosse F, Garaud S, de Leval L. Lymphoproliferative disorders associated with hy-pereosinophilia. Semin Hematol. 2012 49(2):138-48.

Debock I, Delbauve S, Dubois A, Pétein M, Leo O, Goldman M, Flamand V. Th17 allo-immunity prevents neonatal establishment of lymphoid chimerism in IL-4-deprived mice. Am J Transplant. 2012 12(1):81-9.


Debock I, Flamand V. Th2 alloimmunity counteracts Th17-type response in the neona-tal establishment of lymphoid chimerism. Chimerism. 2011 2(4):117-9

Johnson J, Molle C, Aksoy E, Goldman M, Goriely S, Willems F. A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members. Mol Immunol. 2011 48(12-13):1484-93.

Uyttenhove C, Marillier RG, Tacchini-Cottier F, Charmoy M, Caspi RR, Damsker JM, Goriely S, Su D, Van Damme J, Struyf S, Opdenakker G, Van Snick J. Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspec-tives illustrated for GCP-2 in L. major infection. J Leukoc Biol. 2011 89(6):1001-7.

Morampudi V, Braun MY, D'Souza S. Modulation of early β-defensin-2 production as a mechanism developed by type I Toxoplasma gondii to evade human intestinal immuni-ty. Infect Immun. 2011 79(5):2043-50.

Moens E, Brouwer M, Dimova T, Goldman M, Willems F, Vermijlen D. IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17. J Leukoc Biol. 2011 89(5):743-52.

Morampudi V, De Craeye S, Le Moine A, Detienne S, Braun MY, D'Souza S. Partial depletion of CD4(+)CD25(+)Foxp3(+) T regulatory cells significantly increases morbidi-ty during acute phase Toxoplasma gondii infection in resistant BALB/c mice. Microbes Infect. 2011 13(4):394-404.

Hougardy JM, Broeders N, Kianda M, Massart A, Madhoun P, Le Moine A, Hoang AD, Mikhalski D, Wissing KM, Abramowicz D. Conversion from Prograf to Advagraf among kidney transplant recipients results in sustained decrease in tacrolimus exposure. Transplantation. 2011 91(5):566-9.

Blimkie D, Fortuno ES 3rd, Yan H, Cho P, Ho K, Turvey SE, Marchant A, Goriely S, Kollmann TR. Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation. J Immunol Methods. 2011 366(1-2):89-99.

Adams B, Dubois A, Delbauve S, Debock I, Lhommé F, Goldman M, Flamand V. Ex-pansion of regulatory CD8+ CD25+ T cells after neonatal alloimmunization. Clin Exp Immunol. 2011 163(3):354-61.

Van Rompaey N, Le Moine A. Myeloid-derived suppressor cells: characterization and expansion in models of endotoxemia and transplantation. Methods Mol Biol. 2011 677:169-80.

Weatherly K, Braun MY. Organ transplantation: modulation of T-cell activation path-ways initiated by cell surface receptors to suppress graft rejection. Methods Mol Biol. 2011 677:419-30.


Dilek N, van Rompaey N, Le Moine A, Vanhove B. Myeloid-derived suppressor cells in transplantation. Curr Opin Organ Transplant. 2010 15(6):765-8.

de Bellefon LM, Heiman P, Kanaan SB, Azzouz DF, Rak JM, Martin M, Roudier J, Roufosse F, Lambert NC. Cells from a vanished twin as a source of microchimerism 40 years later. Chimerism. 2010 1(2):56-60.

Roufosse F, de Lavareille A, Schandené L, Cogan E, Georgelas A, Wagner L, Xi L, Raffeld M, Goldman M, Gleich GJ, Klion A. Mepolizumab as acorticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome. J Allergy Clin Immunol. 2010 126(4):828-835.e3.

Marichal T, Bedoret D, Mesnil C, Pichavant M, Goriely S, Trottein F, Cataldo D, Gold-man M, Lekeux P, Bureau F, Desmet CJ. Interferon response factor 3 is essential for house dust mite-induced airway allergy. J Allergy Clin Immunol. 2010 126(4):836-844.e13.

Vokaer B, Van Rompaey N, Lemaître PH, Lhommé F, Kubjak C, Benghiat FS, Iwakura Y, Petein M, Field KA, Goldman M, Le Moine A, Charbonnier LM. Critical role of regula-tory T cells in Th17-mediated minor antigen-disparate rejection. J Immunol. 2010 185(6):3417-25.

Epalza C, Goetghebuer T, Hainaut M, Prayez F, Barlow P, Dediste A, Marchant A, Levy J. High incidence of invasive group B streptococcal infections in HIV-exposed unin-fected infants. Pediatrics. 2010 126(3):e631-8.

Burl S, Adetifa UJ, Cox M, Touray E, Ota MO, Marchant A, Whittle H, McShane H, Row-land-Jones SL, Flanagan KL. Delaying bacillus Calmette-Guérin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age. J Immunol. 2010 185(4):2620-8.

Dubois A, Deruytter N, Adams B, Kanda A, Delbauve S, Fleury S, Torres D, François A, Pétein M, Goldman M, Dombrowicz D, Flamand V. Regulation of Th2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life. J Immunol. 2010 185(2):884-91.

Simon HU, Rothenberg ME, Bochner BS, Weller PF, Wardlaw AJ, Wechsler ME, Rosenwasser LJ, Roufosse F, Gleich GJ, Klion AD. Refining the definition of hypereo-sinophilic syndrome. J Allergy Clin Immunol. 2010 126(1):45-9.

Roufosse F, Weller PF. Practical approach to the patient with hypereosinophilia. J Al-lergy Clin Immunol. 2010 126(1):39-44.

Noval Rivas M, Hazzan M, Weatherly K, Gaudray F, Salmon I, Braun MY. NK cell regu-lation of CD4 T cell-mediated graft-versus-host disease. J Immunol. 2010 184(12):6790-8.

Sagoo P, Perucha E, Sawitzki B, Tomiuk S, Stephens DA, Miqueu P, Chapman S, Craciun L, Sergeant R, Brouard S, Rovis F, Jimenez E, Ballow A, Giral M, Rebollo-Mesa I, Le Moine A, Braudeau C, Hilton R, Gerstmayer B, Bourcier K, Sharif A, Krajew-ska M, Lord GM, Roberts I, Goldman M, Wood KJ, Newell K, Seyfert-Margolis V, Warrens AN, Janssen U, Volk HD, Soulillou JP, Hernandez-Fuentes MP, Lechler RI. Development of a cross-platform biomarker signature to detect renal transplant toler-ance in humans. J Clin Invest. 2010 120(6):1848-61.

Poulin LF, Salio M, Griessinger E, Anjos-Afonso F, Craciun L, Chen JL, Keller AM, Joffre O, Zelenay S, Nye E, Le Moine A, Faure F, Donckier V, Sancho D, Cerundolo V, Bonnet D, Reis e Sousa C. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med. 2010 207(6):1261-71.

Vermijlen D, Brouwer M, Donner C, Liesnard C, Tackoen M, Van Rysselberge M, Twité N, Goldman M, Marchant A, Willems F. Human cytomegalovirus elicits fetal gam-madelta T cell responses in utero. J Exp Med. 2010 207(4):807-21.

Nguyen M, Leuridan E, Zhang T, De Wit D, Willems F, Van Damme P, Goldman M, Goriely S. Acquisition of adult-like TLR4 and TLR9 responses during the first year of life. PLoS One. 2010 5(4):e10407.

Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E, Willems F. PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells. Eur J Immunol. 2010 40(2):505-15

Molle C, Goldman M, Goriely S. Critical role of the IFN-stimulated gene factor 3 com-plex in TLR-mediated IL-27p28 gene expression revealing a two-step activation pro-cess. J Immunol. 2010 184(4):1784-92.

Kahn JE, Grandpeix-Guyodo C, Marroun I, Catherinot E, Mellot F, Roufosse F, Blétry O. Sustained response to mepolizumab in refractory Churg-Strauss syndrome. J Aller-gy Clin Immunol. 2010 125(1):267-70.


Bedoret D, Wallemacq H, Marichal T, Desmet C, Quesada Calvo F, Henry E, Closset R, Dewals B, Thielen C, Gustin P, de Leval L, Van Rooijen N, Le Moine A, Vanderplas-schen A, Cataldo D, Drion PV, Moser M, Lekeux P, Bureau F. Lung interstitial macro-phages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest. 2009 119(12):3723-38.

Ogbogu PU, Bochner BS, Butterfield JH, Gleich GJ, Huss-Marp J, Kahn JE, Leiferman KM, Nutman TB, Pfab F, Ring J, Rothenberg ME, Roufosse F, Sajous MH, Sheikh J, Simon D, Simon HU, Stein ML, Wardlaw A, Weller PF, Klion AD. Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol. 2009 124(6):1319-25.e3.

Le Moine A, Vokaer B, Charbonnier LM. A brief focus on memory cells in transplanta-tion. Transplant Proc. 2009 41(8):3361-2.

Ravoet M, Sibille C, Gu C, Libin M, Haibe-Kains B, Sotiriou C, Goldman M, Roufosse F, Willard-Gallo K. Molecular profiling of CD3-CD4+ T cells from patients with the lym-phocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways. Blood. 2009 114(14):2969-83.

Noval Rivas M, Weatherly K, Hazzan M, Vokaer B, Dremier S, Gaudray F, Goldman M, Salmon I, Braun MY. Reviving function in CD4+ T cells adapted to persistent systemic antigen. J Immunol. 2009 183(7):4284-91.

Renneson J, Dutta B, Goriely S, Danis B, Lecomte S, Laes JF, Tabi Z, Goldman M, Marchant A. IL-12 and type I IFN response of neonatal myeloid DC to human CMV in-fection. Eur J Immunol. 2009 39(10):2789-99.

De Wilde V, Van Rompaey N, Hill M, Lebrun JF, Lemaître P, Lhommé F, Kubjak C, Vokaer B, Oldenhove G, Charbonnier LM, Cuturi MC, Goldman M, Le Moine A. Endo-toxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1. Am J Transplant. 2009 9(9):2034-47.

Roufosse F. Hypereosinophilic syndrome variants: diagnostic and therapeutic consid-erations. Haematologica. 2009 94(9):1188-93.

Goriely S, Cavoy R, Goldman M. Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders. Allergy. 2009 64(5):702-9.

Willems F, Vollstedt S, Suter M. Phenotype and function of neonatal DC. Eur J Immu-nol. 2009 39(1):26-35.