Professor, Faculty of Medicine, Université Libre de Bruxelles
Degrees and relevant experienceBSc in Zoology, Université Libre de Bruxelles, Brussels, Belgium
PhD in Immunology, Université Libre de Bruxelles, Brussels, Belgium
Post-doctoral training, NIH, Bethesda, USA
Chercheur Qualifié, FNRS
Current research interests
- Innate immunity in early life
Our research program involves the study of innate and adaptive immunity in early life. The objective of the research is to bring a better knowledge of the higher susceptibility of newborns to pathogens and their limited response to vaccine antigens. The reason is that the innate immune system is still under development and the adaptive system is biaised toward Th2-type responses. We conducted research studies on the shaping of neonatal innate and adaptive immunity and largely documented the unbalanced development of neonatal CD4+ T cell immunity in murine in vivo models. We highlighted the mechanisms that regulate the higher propensity of neonates to development Th2-type response in link with immune tolerance and allergic response. We recently documented the deficient status of follicular helper T cells that are necessary to stimulate properly B lymphocytes to produce antibodies with high-affinity. The current research group is characterizing precursors of dendritic cells that could be efficiently targeted for vaccine in order to generate a protective T cell response against Listeria monocytogenes infection in neonates. We also documented how monocytes could be triggered during Lm infection to regulate the CD8+ T cell response. We also propose to further decipher a new neonatal cross-talk between type 3 innate lymphoid cells involved in the organogenesis and T lymphocytes exposed to Lm.
- Liver inflammatory response
We are studying the inflammatory responses induced during organ surgical procedures like liver ischemia/reperfusion and resection. We conducted translational projects in which we analyze the consequences at the cellular and the molecular levels of the local inflammatory response induced during liver partial resection on the development of colorectal liver metastasis or during Listeria monocytogenes infection. More particularly, we are defining the role of monocytes and Kupffer cells (liver resident macrophages) in these two conditions.
Related publicationsDebock I., and V. Flamand. Unbalanced neonatal CD4+ T cell immunity. 2014. Front Immunol. doi: 10.3389/fimmu.2014.00393
Loi P., Q. Yuan, D. Torres, S. Delbauve, M-A Laute, M-C Lalmand, M. Pétein, S. Goriely, M. Goldman and V. Flamand. Interferon regulatory factor 3 deficiency leads to interleukin-17-mediated liver ischemia-reperfusion injury. 2013. Hepatology. 57:351-61.
Debock I., K. Jaworsky, H. Chadlaoui, S. Delbauve, N. Passon, L. Twyffels, O. Leo and V. Flamand. Neonatal Tfh-cell responses are impaired and modulated by IL-4. 2013. J. Immunol. 191:1231-1239.
Debock I., S. Delbauve, A. Dubois, M. Pétein, O. Leo, M. Goldman and V. Flamand. Th17 alloimmunity prevents neonatal establishment of lymphoid chimerism in IL-4-deprived mice. 2012. Am. J. Transplant. 12:81-9.
Dubois A., N. Deruytter, B. Adams, A. Kanda, S. Delbauve, S. Fleury, D. Torres, A. François, M. Pétein, M. Goldman, D. Dombrowicz and V. Flamand. Regulation of Th2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life. 2010. J.Immunol., 185(2):884-91.